Lean but not hungry: Molecular switch for a healthy metabolism discovered

The protein complex mTORC1 is a central regulator of cell metabolism. In the active state, it stimulates anabolic processes and increases the production and storage of proteins and lipids. Researchers have discovered a mechanism how mTORC1 regulates metabolism: It controls the expression of a specific variant of the transcriptional regulator C/EBP?. Elimination of this variant in mice results in a healthy metabolism, leanness and improved insulin sensitivity. The study may provide a basis for novel strategies for the treatment of metabolic diseases such as obesity and type II diabetes.

from Diet and Weight Loss News -- ScienceDaily http://ift.tt/1C1Nuq8

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