How obesity damages the skeletal muscle metabolism

A decline in metabolism and endurance of skeletal muscle is commonly observed in obese patients, but the underlying mechanism is not well-understood. A research team uncovers a new mechanism to explain how obesity jeopardizes the functions of skeletal muscle and provides a potential treatment against the disease.

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How obesity damages the skeletal muscle metabolism

A decline in metabolism and endurance of skeletal muscle is commonly observed in obese patients, but the underlying mechanism is not well-understood. A research team uncovers a new mechanism to explain how obesity jeopardizes the functions of skeletal muscle and provides a potential treatment against the disease.

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Reduced meat diet has many advantages

Which diet is better: moderately reduce meat consumption and eat more fruit, vegetables and wholegrain products or eating more fish and seafood? Or even switch completely to a vegan diet? A new study shows that the answer to these questions is not as clear-cut as one might think -- depending on which impacts one closely looks.

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Reduced meat diet has many advantages

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Deleting dysfunctional cells alleviates diabetes

Eliminating old, dysfunctional cells in human fat also alleviates signs of diabetes, researchers report. The discovery could lead to new treatments for Type 2 diabetes and other metabolic diseases.

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Deleting dysfunctional cells alleviates diabetes

Eliminating old, dysfunctional cells in human fat also alleviates signs of diabetes, researchers report. The discovery could lead to new treatments for Type 2 diabetes and other metabolic diseases.

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New link between diet, intestinal stem cells and disease discovered

Obesity, diabetes and gastrointestinal cancer are frequently linked to an unhealthy diet. However, the molecular mechanisms responsible for this are not fully understood. Researchers have gained some new insights that help to better understand this connection. These findings provide an important basis for the development of non-invasive therapies.

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New link between diet, intestinal stem cells and disease discovered

Obesity, diabetes and gastrointestinal cancer are frequently linked to an unhealthy diet. However, the molecular mechanisms responsible for this are not fully understood. Researchers have gained some new insights that help to better understand this connection. These findings provide an important basis for the development of non-invasive therapies.

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How eating less in early life could help with reproduction later on

New research shows how switching from a restricted diet to eating as much as you like could be beneficial for reproduction in later life. Researchers studied the eating and mating habits of the small fruit fly Drosophila melanogaster. They found that those that switched from a restricted diet to unlimited food, started mating and reproducing more.

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How eating less in early life could help with reproduction later on

New research shows how switching from a restricted diet to eating as much as you like could be beneficial for reproduction in later life. Researchers studied the eating and mating habits of the small fruit fly Drosophila melanogaster. They found that those that switched from a restricted diet to unlimited food, started mating and reproducing more.

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Insulin in the brain influences dopamins levels

In the human brain, the hormone insulin also acts on the most important neurotransmitter for the reward system, dopamine. Insulin lowers the dopamine level in a specific region of the brain (striatum) that regulates reward processes and cognitive functions, among other things. This interaction can be an important driver of the brain's regulation of glucose metabolism and eating behavior.

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Insulin in the brain influences dopamins levels

In the human brain, the hormone insulin also acts on the most important neurotransmitter for the reward system, dopamine. Insulin lowers the dopamine level in a specific region of the brain (striatum) that regulates reward processes and cognitive functions, among other things. This interaction can be an important driver of the brain's regulation of glucose metabolism and eating behavior.

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Brief 5:2 diet advice is as effective as traditional GP advice, but people like it better, according to new study

A clinical trial has found people prefer receiving information on the 5:2 diet than standard GP weight management advice despite both interventions achieving similar modest weight loss results.

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Brief 5:2 diet advice is as effective as traditional GP advice, but people like it better, according to new study

A clinical trial has found people prefer receiving information on the 5:2 diet than standard GP weight management advice despite both interventions achieving similar modest weight loss results.

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Arterial stiffness in adolescence may potentially cause hypertension and obesity in young adulthood

Arterial stiffness is a novel risk factor to be targeted for preventing and treating hypertension and obesity from a young age, a new study suggests.

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Arterial stiffness in adolescence may potentially cause hypertension and obesity in young adulthood

Arterial stiffness is a novel risk factor to be targeted for preventing and treating hypertension and obesity from a young age, a new study suggests.

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Research in mice shows how diet alters immune system function through a gut microbe

Research in mice demonstrates how diet alters a gut microbe molecule that, in turn, prompts immune cells to downregulate inflammation. The study elucidates molecular mechanism behind long-standing belief that diet, microbiota, and immunity influence one another in myriad ways. If affirmed in larger animals and humans, the findings could inform the design of small-molecule drugs that regulate immune response to treat inflammatory conditions

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Research in mice shows how diet alters immune system function through a gut microbe

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Diet trumps drugs for anti-aging and good metabolic health

A study comparing the impact of diet versus drugs on the inner workings of our cells has found nutrition has a much stronger impact.

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Diet trumps drugs for anti-aging and good metabolic health

A study comparing the impact of diet versus drugs on the inner workings of our cells has found nutrition has a much stronger impact.

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Obesity raises the risk of gum disease by inflating growth of bone-destroying cells

Chronic inflammation caused by obesity may trigger the development of cells that break down bone tissue, including the bone that holds teeth in place, according to new research that sought to improve understanding of the connection between obesity and gum disease. The study, completed in an animal model and published in October in the Journal of Dental Research, found that excessive inflammation resulting from obesity raises the number of myeloid-derived suppressor cells (MDSC), a group of immune cells that increase during illness to regulate immune function. MDSCs, which originate in the bone marrow, develop into a range of different cell types, including osteoclasts (a cell that breaks down bone tissue).

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Obesity raises the risk of gum disease by inflating growth of bone-destroying cells

Chronic inflammation caused by obesity may trigger the development of cells that break down bone tissue, including the bone that holds teeth in place, according to new research that sought to improve understanding of the connection between obesity and gum disease. The study, completed in an animal model and published in October in the Journal of Dental Research, found that excessive inflammation resulting from obesity raises the number of myeloid-derived suppressor cells (MDSC), a group of immune cells that increase during illness to regulate immune function. MDSCs, which originate in the bone marrow, develop into a range of different cell types, including osteoclasts (a cell that breaks down bone tissue).

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Anticoagulant has beneficial side-effects for COVID-19 patients, study finds

Clotting problems and resulting complications are common in COVID-19 patients. Researchers have now shown that a member of the anticoagulant group of drugs not only has a beneficial effect on survival of COVID-19 patients, but also influences the duration of active infection with the SARS-CoV-2 coronavirus.

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PFAS exposure, high-fat diet drive prostate cells’ metabolism into pro-cancer state

A high-fat diet synergizes with exposure to PFAS to change the metabolism of benign and malignant prostate cells, according to a new study in mice.

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Anticoagulant has beneficial side-effects for COVID-19 patients, study finds

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PFAS exposure, high-fat diet drive prostate cells’ metabolism into pro-cancer state

A high-fat diet synergizes with exposure to PFAS to change the metabolism of benign and malignant prostate cells, according to a new study in mice.

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Gut microbiota differences seen in people with autism may be due to dietary preferences

Research suggested that autism spectrum disorder (ASD) may be at least partly caused by differences in the composition of the gut microbiota, based on the observation that certain types of microbes are more common in people with autism. But a new study suggests that the link may actually work the other way around: the diversity in species found in the guts of children with autism may be due to their restricted dietary preferences associated with autism, rather than the cause of their symptoms.

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Gut microbiota differences seen in people with autism may be due to dietary preferences

Research suggested that autism spectrum disorder (ASD) may be at least partly caused by differences in the composition of the gut microbiota, based on the observation that certain types of microbes are more common in people with autism. But a new study suggests that the link may actually work the other way around: the diversity in species found in the guts of children with autism may be due to their restricted dietary preferences associated with autism, rather than the cause of their symptoms.

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Plant-based alternative food consumption may have doubled in UK over ten years suggests first analysis of its kind

The proportion of UK people reporting eating and drinking plant-based alternative foods such as plant-based milk, vegan sausages and vegetable burgers nearly doubled between 2008 -- 2011 and 2017 -- 2019, according to a new study.

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Supportive strategies help 'picky eaters' deal with food aversions

In a large national survey, adults who struggled with picky eating habits as children overwhelmingly said they benefitted more from positive and encouraging strategies their parents used than forceful or coercive approaches.

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Plant-based alternative food consumption may have doubled in UK over ten years suggests first analysis of its kind

The proportion of UK people reporting eating and drinking plant-based alternative foods such as plant-based milk, vegan sausages and vegetable burgers nearly doubled between 2008 -- 2011 and 2017 -- 2019, according to a new study.

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Supportive strategies help 'picky eaters' deal with food aversions

In a large national survey, adults who struggled with picky eating habits as children overwhelmingly said they benefitted more from positive and encouraging strategies their parents used than forceful or coercive approaches.

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A newly discovered genetic link to non-alcoholic inflammatory liver disease

Researchers have shown that albino mice of the C57BL/6 line are highly susceptible to developing the inflammatory liver condition non-alcoholic steatohepatitis (NASH) when fed a high cholesterol diet. The albino mice carry a mutation in the tyrosinase gene leading to a deficiency of melanin synthesis. NASH is a serious illness in humans, and the identification of the involvement of tyrosinase in NASH development will guide future research into this condition.

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A newly discovered genetic link to non-alcoholic inflammatory liver disease

Researchers have shown that albino mice of the C57BL/6 line are highly susceptible to developing the inflammatory liver condition non-alcoholic steatohepatitis (NASH) when fed a high cholesterol diet. The albino mice carry a mutation in the tyrosinase gene leading to a deficiency of melanin synthesis. NASH is a serious illness in humans, and the identification of the involvement of tyrosinase in NASH development will guide future research into this condition.

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Fat-secreted molecule lowers response to common cancer treatment

Leptin, a molecule produced by fat cells, appears to cancel out the effects of the estrogen-blocking therapy tamoxifen, a drug commonly used to treat and prevent breast cancers, suggests a new study.

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Fat-secreted molecule lowers response to common cancer treatment

Leptin, a molecule produced by fat cells, appears to cancel out the effects of the estrogen-blocking therapy tamoxifen, a drug commonly used to treat and prevent breast cancers, suggests a new study.

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Galectin-1 linked to increased risk of type 2 diabetes

Researchers now associate elevated levels of the protein galectin-1 with increased risk of developing type 2 diabetes about 18 years later. At the same time, this protein seems to be a protective factor for the kidneys among type 2 diabetes patients at high risk for diabetic nephropathy.

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Galectin-1 linked to increased risk of type 2 diabetes

Researchers now associate elevated levels of the protein galectin-1 with increased risk of developing type 2 diabetes about 18 years later. At the same time, this protein seems to be a protective factor for the kidneys among type 2 diabetes patients at high risk for diabetic nephropathy.

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Bood metabolites associated with coffee consumption may affect kidney disease risk

Researchers have identified several metabolites in the blood whose levels are altered by coffee consumption. Levels of 3 of these coffee-related metabolites were significantly associated with individuals' risk of developing chronic kidney disease.

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Bood metabolites associated with coffee consumption may affect kidney disease risk

Researchers have identified several metabolites in the blood whose levels are altered by coffee consumption. Levels of 3 of these coffee-related metabolites were significantly associated with individuals' risk of developing chronic kidney disease.

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Save the planet (and your health) by steering clear of sweets and pastries

Need another reason to cut back on sugary foods and drinks, apart from an expanding waistline? They're not helping the environment, contributing to a higher cropland, water scarcity and ecological footprint, according to a new review.

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Save the planet (and your health) by steering clear of sweets and pastries

Need another reason to cut back on sugary foods and drinks, apart from an expanding waistline? They're not helping the environment, contributing to a higher cropland, water scarcity and ecological footprint, according to a new review.

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One in 20 achieve remission from type 2 diabetes, Scottish study finds

Around one in 20 people in Scotland diagnosed with type 2 diabetes achieve remission from the disease, according to new research. This suggests people are achieving remission outside of research trials and without bariatric surgery.

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One in 20 achieve remission from type 2 diabetes, Scottish study finds

Around one in 20 people in Scotland diagnosed with type 2 diabetes achieve remission from the disease, according to new research. This suggests people are achieving remission outside of research trials and without bariatric surgery.

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Mother’s weight before – not gained during – pregnancy has impact on development of allergic diseases

A new study of nearly 250,000 children in Ontario over seven years found a mother's weight before pregnancy may impact their newborn's risk of developing allergic diseases in early childhood, whereas weight gain during pregnancy did not seem to have the same effect.

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Mother’s weight before – not gained during – pregnancy has impact on development of allergic diseases

A new study of nearly 250,000 children in Ontario over seven years found a mother's weight before pregnancy may impact their newborn's risk of developing allergic diseases in early childhood, whereas weight gain during pregnancy did not seem to have the same effect.

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Forest fires linked to low birth weight in newborns

Women exposed to smoke from landscape fires during pregnancy are more likely to give birth to babies with low or very low birth weights, according to new findings.

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Forest fires linked to low birth weight in newborns

Women exposed to smoke from landscape fires during pregnancy are more likely to give birth to babies with low or very low birth weights, according to new findings.

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Three ways to reduce the carbon footprint of food purchased by US households

Most consumers want to make food purchases that are smart for their wallets, their health and the environment. And while switching to a vegetarian or vegan diet can lower one's impact on greenhouse gas emissions, it may not be realistic or healthful for everyone. Now, researchers report three ways that Americans can reduce the carbon footprint of their food purchases, without requiring drastic dietary changes.

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Three ways to reduce the carbon footprint of food purchased by US households

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Potential strategy for fighting obesity

Scientists may have identified a method of safely mimicking the weight-loss benefits of a plant compound that -- despite its harmful side effects -- hold critical answers to developing therapies for obesity.

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